Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitivesource of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
The comprehensive nature of this text will appeal To many physicians, the study of sinus disease to a wide range of physicians including generalists, reflects a discipline only slightly less interesting otolaryngologists, and allergists. Family physi- than a Johnson and Johnson gauze pad, a pursuit cians, internists, pediatricians, and allergists will followed by dilettanti and eccentric professors. To each profit from having a single source that pro- others, it represents a subsection of an undefined vides an in-depth review of topics pertaining to discipline that crosses barriers of internal medi- sinus diseases. The otolaryngologist will benefit cine, pediatrics, allergy, chest disease, and oto- from having a single text that provides a detailed laryngology. To patients, sinus problems are discussion of the many ancillary medical problems synonymous with headaches and a chronic source of morbidity. Yet few physicians have been pre- that influence sinus function and, therefore, surgi- cal outcome. We hope that all readers will enjoy the pared, until recently, to do much more than pre- international choice of authors whose topics have scribe antibiotics, intranasal steroids, antihistamines, been purposely allowed to overlap in an effort to and commiserate for the misery involved. Fortu- provide the broadest possible scope of informa- nately, this picture shows significant signs of tion. We expect Diseases of the Sinuses to serve as impending remission. The disciplines of clinical immunology, allergy, and otolaryngology have the foundation of an ever-stronger ongoing effort to combat sinus disease.
The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (onco genes). This text will explore the known molecular genetic, biolog ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic virus and those cytogenetic alterations that either cause or are caused by oncogene activation. The text first reviews the cytogenetics of human cancers link ing classical cytogenetics and molecular genetics. Avery A. Sand berg (Roswell Park Memorial Institute, Buffalo, New York) reviews the leukemias and lymphomas, followed by S. Pathak (M. D. Anderson Hospital and Tumor Institute, Houston, Texas), who reviews solid tumors. Functional consideration of oncogenes is highlighted by Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland) through their description of the v-sis locus sis and its gene product p.28 ; a protein that closely resembles human platelet-derived growth factor (PDGF).
Author Ruth Brown was born with mastocytosis, a rare, complex, and little-known disease responsible for producing a multitude of diverse symptoms. As a result of her condition, she experienced many incredible encounters with medical professionals and institutions. In "Surviving Medical Care," she writes of the nearly fifty-five years she spent seeking medical attention for a series of seemingly unrelated and sporadic symptoms.
While living a relatively normal life as a wife, mother, and software developer, she coped with the challenges of her affliction. As her condition worsened, she desperately sought a correct medical diagnosis and appropriate treatment. In her frequent visits with medical professionals, her care ranged from outstanding to poor and even horrifically negligent. Despite numerous obstacles, she never lost her optimism or her sense of humor.
In this memoir, Brown shares how her extensive experience as a patient exemplifies pitfalls of medical care in the United States. Her problems arose not from a lack of excellent medical coverage but from a variety of other problems: physicians with poor communication skills; unnecessary, costly and invasive testing; medical personnel not trained to think logically or creatively; tight schedules in physicians' offices; overcrowded and understaffed emergency rooms; and indifferent physicians.
While "Surviving Medical Care" narrates Brown's personal story, it has much to say about how Americans need to be involved in their medical care and advocate for improvements in the medical system.
Human clustering in coastal areas The coastal zone has gained a solid reputation as a place vocated for recreational activities and this is generally related to the presence of the sea. The relationship, however, does not appear univocal or simple: the sea can be perceived as a hostile element by humans and the more general question of whether the presence of the shore is in itself a favourable, repulsive, or irrelevant factor to settlement is a debatable point, at least for pre-industrial societies. Back in the early part of the 19th century, Friedrich Hegel regarded oceans and rivers as unifying elements rather than dividing ones, thus implying a trend towards the concentration of human settlements along them. 'The sea', he wrote, 'stimulates 1 courage and conquest, as well as profit and plunder', although he realized that this did not equally apply to all maritime peoples. In Hegel's view, different approaches to the sea were mainly the results of cultural factors and, in fact, he recognized that some people living in coastal areas perceive the sea as a dangerous and alien place and the shore as aftnis terrae.