The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (onco genes). This text will explore the known molecular genetic, biolog ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic virus and those cytogenetic alterations that either cause or are caused by oncogene activation. The text first reviews the cytogenetics of human cancers link ing classical cytogenetics and molecular genetics. Avery A. Sand berg (Roswell Park Memorial Institute, Buffalo, New York) reviews the leukemias and lymphomas, followed by S. Pathak (M. D. Anderson Hospital and Tumor Institute, Houston, Texas), who reviews solid tumors. Functional consideration of oncogenes is highlighted by Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland) through their description of the v-sis locus sis and its gene product p.28 ; a protein that closely resembles human platelet-derived growth factor (PDGF).
This unique two-part discussion of foxglove--the herb from which digitalis is derived--features a facsimile of William Withering's classic "An Account of Foxglove and Some of its Medical Uses," complete with explanatory notes interpreting this eighteenth century text for the modern reader. The second part of the book, written by J.K. Aronson, co-author of the Oxford Textbook of Clinical Pharmacology, includes an introduction to the botany and pharmacology of foxgloves, their therapeutic uses before Withering, a short biography of Withering, an account of 18th century medical practices, and finally a review of the uses of digitalis in modern medicine.
Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitivesource of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
The new "Medical Evaluation of Child Sexual Abuse: A Practical Guide" will serve as both a key reference for primary care pediatricians as well as pediatricians who are focusing their clinical work on child maltreatment and in particular sexual victimization. The book will walk the clinician through formulation of a diagnosis, differential and diagnostic dilemmas, how to formulate conclusions, and the nuances of documentation.
Before 1750 Addingham was a small farming community but during the next 100 years (the period covered by this book) the village was transformed by the coming of the textile industry and the construction of substantial mills and related enterprises. This expansion produced wealthy mill owners who needed suitable housing for themselves and their families and also lesser properties for their workers. It is very fortunate that so many houses of this period still exist in Addingham (which has over 100 listed buildings) and, indeed, much of Main Street is still lined by original buildings. In the first part of this book, local historian Arnold Pacey has written chapters about the principle property owners, particularly the Cunliffes and the Cockshotts, and describes the houses that they built, with detailed pen and ink drawings (mainly by the author) of architectural features, and photographs of some of the houses. The second part of the book is devoted to the builders, stonemasons and other craftsmen who built the houses and the distinctive working methods which left their mark and show who built which house. Particularly featured here are generations of the Breare family. The second edition, published 2015, has the addition of an old photograph of North Street which has provided the author with further information about the houses in that street and enabled related changes and additions to the text.