The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (oncoÂ genes). This text will explore the known molecular genetic, biologÂ ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic virus and those cytogenetic alterations that either cause or are caused by oncogene activation. The text first reviews the cytogenetics of human cancers linkÂ ing classical cytogenetics and molecular genetics. Avery A. SandÂ berg (Roswell Park Memorial Institute, Buffalo, New York) reviews the leukemias and lymphomas, followed by S. Pathak (M. D. Anderson Hospital and Tumor Institute, Houston, Texas), who reviews solid tumors. Functional consideration of oncogenes is highlighted by Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland) through their description of the v-sis locus sis and its gene product p.28 ; a protein that closely resembles human platelet-derived growth factor (PDGF).
The comprehensive nature of this text will appeal To many physicians, the study of sinus disease to a wide range of physicians including generalists, reflects a discipline only slightly less interesting otolaryngologists, and allergists. Family physi- than a Johnson and Johnson gauze pad, a pursuit cians, internists, pediatricians, and allergists will followed by dilettanti and eccentric professors. To each profit from having a single source that pro- others, it represents a subsection of an undefined vides an in-depth review of topics pertaining to discipline that crosses barriers of internal medi- sinus diseases. The otolaryngologist will benefit cine, pediatrics, allergy, chest disease, and oto- from having a single text that provides a detailed laryngology. To patients, sinus problems are discussion of the many ancillary medical problems synonymous with headaches and a chronic source of morbidity. Yet few physicians have been pre- that influence sinus function and, therefore, surgi- cal outcome. We hope that all readers will enjoy the pared, until recently, to do much more than pre- international choice of authors whose topics have scribe antibiotics, intranasal steroids, antihistamines, been purposely allowed to overlap in an effort to and commiserate for the misery involved. Fortu- provide the broadest possible scope of informa- nately, this picture shows significant signs of tion. We expect Diseases of the Sinuses to serve as impending remission. The disciplines of clinical immunology, allergy, and otolaryngology have the foundation of an ever-stronger ongoing effort to combat sinus disease.
Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitivesource of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
One of the first applications of ultrasound was in submarine sonar equip- ment. Since then ultrasound has found increasing applications, particularly in industry, but increasingly in biomedicine. For many years ultrasound has been used in physical therapy, although only in the past decade or two has it evolved from laboratory curiosity to a well-established diagnostic imaging modality. Ultrasound is now a widely accepted, indeed pervasive, diagnos- tic and therapeutic tool in the medical field, and its applications are increasing rapidly. Our intent in developing this book is to provide a coherent tutorial intro- duction to the field of medical ultrasound at a level suitable for those en- tering the area from either medical or scientific backgrounds. The topics discussed should be of interest to nearly all medical and health care per- sonnel needing to understand or operate ultrasonic devices, including clini- cians, medical technicians, physiotherapists, medical physicists, and other biomedical scientists interested in the field. The book opens with a description of the basic principles of propagating acoustic waves, explains how they interact with a wide range of biological systems, and outlines the effects they produce. To provide practical infor- mation to operators of ultrasound equipment, we have included thorough coverage of the details of ultrasonic instrumentation and measurement techniques, and set forth the framework for an effective quality assurance program.